Thursday, August 27, 2020

The Best of Daily Writing Tips in 2011

The Best of Daily Writing Tips in 2011 The Best of Daily Writing Tips in 2011 The Best of Daily Writing Tips in 2011 By Daniel Scocco Above all else cheerful new year to all the Daily Writing Tips perusers! Have confidence well continue sending you our best composing tips in 2012. Beneath youll discover a gathering of the most visited posts we distributed in 2011. Ensure you havent missed any! 100 Mostly Small But Expressive Interjections 7 Grammatical Errors That Aren’t 100 Beautiful and Ugly Words 10 Latin Abbreviations You Might Be Using Incorrectly 100 Whimsical Words Would it be a good idea for you to Self-Publish? 50 Problem Words and Phrases 20 Classic Novels You Can Read in One Sitting Who Cares About â€Å"Whom† Anymore? How Spelling Diverges Between American and British English 10 Words That Don’t Mean What You May Think They Do 10 Comma Cases in Which More Is More 10 Pairs of Similar-Looking Near Antonyms 150 Foreign Expressions to Inspire You Is â€Å"They† Acceptable as a Singular Pronoun? 50 Redundant Phrases to Avoid 10 Intensifiers You Should Really, Absolutely Avoid The Other N-Words 7 Editing Pet Peeves 8 Steps to More Concise Writing Need to improve your English in a short time a day? Get a membership and begin accepting our composing tips and activities day by day! Continue learning! Peruse the General classification, check our well known posts, or pick a related post below:7 Types of Narrative Conflict20 Words Meaning Being or Existing in the PastUsing zeitgeist Coherently

Saturday, August 22, 2020

Strengthening Financial Reporting Framework

Question: Examine about the Strengthening Financial Reporting Framework. Answer: Presentation: The title of the theme is True and Fair View An examination with Regulatory structure. This is predominantly centered around how the valid and reasonable view idea has been created throughout the years and has been before known by the various names. The idea of valid and reasonable view is relevant not just on the budget summaries of the organization yet additionally on the different business managing entered by the people or the organization. The paper has begun with the presentation. At that point the writing survey has been given with respect to the history and motivation behind the valid and reasonable view idea and the help that the idea have increased throughout the years. From that point, the end has been given alongside the official synopsis of the writing survey. The information has been gotten from the applicable sources. The idea of valid and reasonable view has been the significant idea for the organizations as well as the people, evaluators and the chiefs of the organization including the people those accused of Governance. Through this the associations have come to think about the importance of the budget summaries and that too with the valid and reasonable view and come to think about the criticalness of the pertinence of bookkeeping norms and its legitimate consistence. Through this writing survey it has been set up that the idea has picked up the superseding impact over the bookkeeping measures and it has nothing to do with the rebelliousness of the bookkeeping standard. The examination has point by point that however use of bookkeeping measures is important yet to keep up the pertinence and unwavering quality of the budget summaries, the valid and reasonable view must be built up. In this manner, the audit has given the significance of valid and reasonable idea in the business world. References Australian Government Official Website, (2017), Strengthening the Financial Reporting Framework accessible at got to on 21/04/2017. Loads R and Wolnizer P, (2011), A True and Fair View of position and results: the authentic foundation accessible at got to on 21/04/2017. Deegan C, (2010), An Overview of the Australian External announcing Environment, accessible at got to on 21/04/2017. FRC, (2014), True and Fair Statement accessible at - exercises/specialized assets search/2014/june/frc-genuine fair.html got to on 21/04/2017. Karan R, (2012), Irreconcilable Legal and Accounting Views of a True and Fair View: A developing option from Australian, accessible qt got to on 21/04/2017. Vladu An and Matis D, (2012), True and Fair View and Creative Accounting Conceptual Delimitations Based on Papineaus Tree Methodology, accessible at got to on 21/04/2017.

Friday, August 21, 2020

Foreign Market Entry and Diversification Research Paper - 3

Remote Market Entry and Diversification - Research Paper Example y differentiate for better chances, to use the abilities just as capacities by method for venturing into business where the firm’s assets can be utilized as serious resources. Additionally to some broaden expanding will assist the organization with minimizing the hazard however as pointed before the hazard included is high. There is no assurance that the business will succeed (Rao, et al, 2009, 228). The distributing organization which manages books and other distributing things should proceed with its business and go for related broadening. The distributing organization ought to select related enhancement procedure and include into procurement of business which are connected as far as innovation, items or markets. Related broadening likewise named as concentric expansion happens whenever consolidated benefit will in general increment the chances and qualities and in this way limits the dangers and shortcoming (Orcullo, 2008, 76). In this manner the distributing firm may look for new business whose item, advertise, circulation is like that of its own and where obtaining would result in â€Å"synergy.† Thus the organization so as to make cooperative energy ought to go into related expansion and offer assets and capacities with its current specialty unit. With the development of on the web and advanced media, the distributing business has been experiencing critical changes. Accordingly considering the present circumstance the distributing business ought to enhance its business into rising and creating nations and simultaneously follows the rising patterns in the distributing business which resemble eBooks, web journals, versatile distributing alongside independently publishing (ICMR, 2007). While enhancing the business the distributing organization can select vital partnership. Vital coalitions are shaped through association between the organizations and joining the assets, capacities and center abilities and seek after a common enthusiasm to create, make and furthermore fabricate merchandise (KAZMI, 2008. 187). The partnership is a

Tuesday, May 26, 2020

The Irish education system has been constantly evolving...

The Irish education system has been constantly evolving through the influences of philosophy, social changes and the history of the state. It is my opinion that the sociological changes have had a massive influence on the policies that have been implemented into the Irish education system. The policy that I will be focusing on is one of equal education opportunities for everyone with a focus on the sociological side to these changes. I will be looking at the policy of an equal education in terms of social class and gender. In the early nineteenth century education was only open to the children of upper and middle class families, this was especially true for second and third level education. The reason for this was twofold, firstly†¦show more content†¦There was a series of important policies that enhanced the ability to reach secondary education for all of society, for example, in 1959 Sean Lemass TD announced there would be improved facilities for secondary schools and in 1964 the Minster for Education Patrick Hillery TD announced that the government would begin opening state-funded comprehensive and community schools. One of the key philosophies of education has been ingrained in our Constitution. Article 42 states that The State shall provide for free primary education and shall endeavour to supplement and give reasonable aid to private and corporate educational initiative (Bunreacht na hÉireann, 1937) . Although this is specific to primary education, as already mentioned, this was expanded into secondary education. Educational philosopher, Randall Curren describes education as a social right saying we must assign society and its government an obligation to provide the child with an education (Curren 2009). The Free Education Scheme was a policy put forward by Lemass government in 1967 in an attempt to deal with the educational inequalities in Ireland. Coolahan described this new policy as a social escalator which allowed low income families, that otherwise would have struggled to send their children to secondary school and escape the social class they found themselves in, to do so. Childrens education was no longer governed by aShow MoreRelatedCultural Analysis For Doing Business8067 Words   |  33 Pagestackled using scholarly articles found through the Internet and Liberty Online Library Database. While conducting this research, a long period was spent reading through the articles to find points of relevance to this paper, while adding some unique attributes to this paper as well. Anyone wishing to conduct business in Ireland, want to find out about Irish people, or have an interest in traveling to Ireland, will learn all they need to know while reading through this paper. Keywords: Ireland, cultureRead MoreEssay on The History of Conflict in Ireland14775 Words   |  60 PagesThe History of Conflict in Ireland An American audience may find it difficult to comprehend the sense of history which is in the Irish conflict. It goes back to the 1920s when the island was partitioned, and Catholics in Northern Ireland believed that they were on the wrong side of that border, and believed that they had been done out of their political heritage. But Protestants have a sense of history which goes back to at least the seventeenth century, where fromRead MoreCase Studies: Sas Airline Ryanair80169 Words   |  321 Pageslate spring!! It has been a great experience and adventure up there in Northern Sweden!! We will miss you†¦ Finally we would like to thank particularly the Studentexpedition for its kindness, without forgetting our family and friends (from Sweden, France, Portugal and Greece) for their everlasting daily support, especially during hard moments. Many thanks to all of you! Umeà ¥, 24 June 2007 Gilles HELTERLIN Nuno BERBERAN Abstract The dynamics of business contexts influence the way firms actRead MoreHow Change Is An Tool For Organisational Development And The Pace Of Change Essay9720 Words   |  39 PagesCHAPTER ONE INTRODUCTION In today’s increasingly competitive world, change has been described as an important tool for organisational development and the pace of change is primarily attributed to the ever increasing challenges such as competition, development, communication, merges and acquisition, technology and general instability. Workplaces are faced with endless change (Herscovitch Meyers, 2002) and effective management of that change is an effective competency currently required by an organisationRead MoreExploring Corporate Strategy - Case164366 Words   |  658 PagesCASE STUDIES ECS8C_C01.qxd 22/10/2007 11:54 Page 598 ECS8C_C01.qxd 22/10/2007 11:54 Page 599 Guide to using the case studies The main text of this book includes 87 short illustrations and 15 case examples which have been chosen to enlarge speciï ¬ c issues in the text and/or provide practical examples of how business and public sector organisations are managing strategic issues. The case studies which follow allow the reader to extend this linking of theory and practiceRead MoreGeorge Orwell23689 Words   |  95 Pageskind-hearted lawabiding men who would never dream of committing murder in private life. On the other hand, if one of them succeeds in blowing me to pieces with a well-placed bomb, he will never sleep any the worse for it. He is serving his country, which has the power to absolve him from evil. One cannot see the modern world as it is unless one recognizes the overwhelming strength of patriotism, national loyalty. In certain circumstances it can break down, at certain levels of civilization it does not existRead MoreOrganisational Theory230255 Words   |  922 PagesUniversity, UK McAuley et al. provide a highly readable account of ideas, perspectives and practices of organization. By thoroughly explaining, analyzing and exploring organization theory the book increases the understanding of a field that in recent years has become ever more fragmented. Organization theory is central to managing, organizing and reflecting on both formal and informal structures, and in this respect you will find this book timely, interesting and valuable. Peter Holdt Christensen, AssociateRead MorePropaganda by Edward L Bernays34079 Words   |  137 Pages......... THE NEW PROPAGANDISTS .... 9 19 32 47 62 THE PSYCHOLOGY OF PUBLIC RELATIONS BUSINESS AND THE PUBLIC .... PROPAGANDA AND POLITICAL LEADERSHIP 92 WOMENS ACTIVITIES AND PROPAGANDA . . . 115 121 135 141 150 PROPAGANDA FOR EDUCATION PROPAGANDA IN SOCIAL SERVICE . ART AND SCIENCE ..................................................... THE MECHANICS OF PROPAGANDA . . CHAPTER I ORGANIZING CHAOS THE conscious and intelligent manipulation of the organized habits and opinionsRead MoreCase Study148348 Words   |  594 Pages978-0-273-73557-1 (printed) ISBN: 978-0-273-73552-6 (web) ï £ © Pearson Education Limited 2011 Lecturers adopting the main text are permitted to download and photocopy the manual as required. Pearson Education Limited Edinburgh Gate Harlow Essex CM20 2JE England and Associated Companies around the world. Visit us on the World Wide Web at: ---------------------------------This edition published 2011  © Pearson Education Limited 2011 The rights of Gerry Johnson, Richard Whittington andRead MoreI Love Reading Essay69689 Words   |  279 PagesCommission, 2008 This report has been prepared by Amlanjyoti Goswami, Namita Dalmia and Megha Pradhan with support and guidance from Dr. Ashok Kolaskar and Mr. Sunil Bahri. Table of Contents Acknowledgements Executive Summary Chapter I Chapter II Chapter III Chapter IV Chapter V Chapter VI Chapter VII Annexure I : : : : : : : : Introduction: Why Entrepreneurship What Motivates Entrepreneurship Socio-cultural Factors Access to Early Stage Finance Education, Innovation and Entrepreneurship

Friday, May 15, 2020

Essay on Filtering in Libraries and Schools - 679 Words

Filtering in Libraries and Schools We read about blocking some kinds of internet sites in public libraries and schools by using filtering software. There are problems on how to define an obscene piece of material, the list of filtered sites is not available to user , restricting access of adults, not just children, and affecting the lives of poor people who cannot afford PCs by filtering many sites. I think everyone agrees that we should protect children from harmful sites. However, it is difficult to make a restriction which is acceptable by all users. How should filtering systems changed ? There is an expression in the textbook that is concerning the right to see porn in libraries(Basse,†¦show more content†¦A visitor should a library card which proves the age of the user, and users can operate the appropriate filtering software by sliding the his or her card I think it is a good idea because it protects children from inappropriate things by using different filtering software in concerning their age as well as protecting the right of adults to see them. Using this system at home and in schools may also be a good idea. iTECH Inc. provides a filtering software which can change filtering level by age (iTECH Inc.).However, only checking the age of the user may not enough. There was an argument about whether sites which tells how to make bomb for farming should be filtered (Basse Sara,p207). I think it is necessary to check the job of the user if a lot of farmers want to know about making bomb online. However, how can filtering software companies define if each site is appropriate for each user ? I have an idea for this problem too. How about each site â€Å"register† to World Wide Web in some ways when it is created and declare what kind of site it is? Filtering software company check every new site and decide the level of filtering. For example, the site which shows the picture of breast such as the site of breasts is at the level for age 12 and higher . No site can be seen on the Web without registering.Show MoreRelatedLibraries Should Use Software Filters for Internet Access887 Words   |  4 PagesLibraries Should Use Software Filters for Internet Access Public libraries provide us with a large amount of information. Residents can borrow books from libraries. Libraries also provide Internet access for everyone, including children. Since parents cannot control what then children are seeing on the Internet in libraries, children can access pornographic or violent sites easily. So, public libraries should restrict Internet access by utilizing filtering software to prevent children from seeingRead MoreCensorship Is Not Limited Repressive Regimes Or Network Television?1522 Words   |  7 Pagesinternet being heavily censored in school. The Children’s Internet Protection Act (CIPA) was signed into law in 2000; the law requires any public schools or library to filter any inappropriate content from the computers being used by minors. Since the law has been put in place, schools across America have installed programs that use keywords to designate certain types of websites off-limits to students while using the schools internet serve r. The problem with these filtering programs is that they blockRead More Internet Censorship Essay - Censoring the Internet740 Words   |  3 Pagesof Congress and the House of Representatives are working on bills that will filter out such sites. For example, the Pennsylvania House of Representatives voted on a bill that requires public libraries to install filtering software (Rogers). The bills sponsor said sexual predators are using public libraries to access pornography and prey on children there (Rogers). Porn sites tend to use popular keywords so that innocuous searches result in X-rated hits. Visitors to non-sexual sites are redirectedRead MoreEssay on Censorship in Libraries and Schools1074 Words   |  5 PagesCensorship in Libraries and Schools What would you do if you went to your childs school and saw that they were looking at inappropriate material on the internet? Would you react the same way if they were in a public library? Who decides what is okay for your children to view? Who decides where they can view it? What can you do about them being able to view these things? Are there any laws that can prevent this from happening? What are some schools and libraries doing to help prevent childrenRead MoreInternet Filters Should Be Mandatory For Students Under The Age Of 181605 Words   |  7 Pagesprod their online acquaintances to exchange personal information, such as addresses and phone numbers, thus putting the kids they are chatting with—and their families—at risk† (, 2016). With Internet filtering systems being installed will prevent students under the age of 18 from viewing inappropriate content, and other Internet users from discovering informatio n about the young user. However, despite the internet being a dangerous place, this issue isRead MorePublic Libraries Should Not Block Internet Pornography1813 Words   |  8 Pages Since the internet has been available in schools and libraries in this country, there has been a debate about what should be accessible to users, especially minors. The amount of information disseminated on the world wide web is vast, with some sources valuable for scholarly and personal research and entertainment, and some sources that contain material that is objectionable to some (ie. pornography, gambling, hate groups sites, violent materials). Some information potentially accessible on theRead More Internet Censorship Libraries Essay2768 Words   |  12 Pagesshould they filter what information is available to its visitors via the Internet? This scenario is being debated all across the United States. Many states are arguing over whether or not the library has the authority to limit what information is accessible via the Internet computers at the library. The argument is over the First Amendment right of Free Speech. There are family groups who are actually in favor of a llowing unfiltered access on the Internet, not what one would think. These groupsRead More Free Speech Essay2089 Words   |  9 PagesResponsibility’s (CPSR) Frequently Asked Questions on filtering, a content filter is one or more pieces of software that work together to prevent users from viewing material found on the Internet and is described by the Electronic Frontier Foundation as a software mechanism for sorting content into categories for the purpose of decreasing the accessibility of certain types of content. All aspects of internet filters will be discussed including who chooses to use filtering software, why these groups use filtersRead MoreEssay on Filters Are Needed to Protect Children From the Internet1924 Words   |  8 Pagespublic libraries by mandating the use of filtering software, the so-called Internet Nannies.      Ã‚  Ã‚   Being relatively new, the Internet standards of regulation have not been completely set.   Many forms of legislation have been made in regards to regulation, and many are still being developed and decided in courts right now. In particular, the First Amendment protection as it relates to Internet content has not yet been determined (Internet Filtering Software)Read More Blocking Filtering Essay1631 Words   |  7 Pagesquot; U.S. Supreme Court majority decision, Reno v. ACLU (June 26, 1997) Blocking and filtering software for the Internet is one of the most hotly debated topics regarding free speech and the Internet. Many have criticized blocking software for being both under and over inclusive, and others have argued that blocking software should not be used at all in public institutions such as libraries and schools. On the other side, supporters of blocking software claim that is a legitimate method to regulate

Wednesday, May 6, 2020

Social Norms Of The Pledge Class Subculture - 1441 Words

Social Norms of the Pledge Class Subculture The norms of a social group vary depending on who the group consists of, what the group represents, when the group is together, where the group is located, and how large the group is. The norms of a culture are rules and expectations by which a society guides the behavior of its members (Macionis 58). A subculture refers to cultural patterns that set apart some segment of a society’s population (Macionis 64). Here at Saint Francis University, sororities are a subculture of the campus’s society and inside that subculture the pledge class can be found. Each sorority represents a chapter, in turn each chapter is specific to a certain sorority. The chapter is a single branch of a specific national sorority that is represented at the campus. Each chapter is represented by Greek words and letters, for example Saint Francis University has six sororities on its campus. These sororities are Delta Phi Epsilon (ΔÎ ¦ÃŽâ€¢), Ga mma Sigma Sigma (ΓÎ £ÃŽ £), Omega Zeta Nu (ÃŽ ©ÃŽâ€"ÃŽ ), Phi Delta Kappa (ÃŽ ¦ÃŽâ€ÃŽÅ¡), Phi Lambda Psi (ÃŽ ¦ÃŽâ€ºÃŽ ¨), and Theta Phi Alpha (ΘÎ ¦ÃŽâ€˜). A sorority’s letters can be worn by each member of the sorority. Some sororities do not allow the new pledge class to wear their sorority’s letters until the girls are official members. Pledge week is a number of events that the pledges are required to attend to be initiated into the sorority officially. Initiation day is the day when all the pledges that have met the requirements and stayed withinShow MoreRelatedSociology Studies On Social And Institutions Of The Individual And Groups1170 Words   |  5 Pagesall aspects of society including social relationships and institutions of the individual and groups. Sociology studies social interactions, relationships, and culture. Sociologist are interested in learning about how the social process influences human behavior and feelings in addition to their thought process. There is a wide range of topics that sociologists study. There are topics that are on a societal level such as the divisions in social class and race, social movements, deviance, education,Read MoreNotes Ap Comparative Government2027 Words   |  9 PagesChapter Three Notes Political Culture and Political Socialization * Each nation has its own political norms that influence how people think about and react to politics. * American’s strong feelings of patriotism, the Japanese deference to political elites, and the French proclivity for protest all illustrate how cultural norms shape political. * When a new regime forms, a supportive public can help develop the new system, while the absence of public support may weaken the new systemRead MoreMacro-Environmental Analysis of Us Market3959 Words   |  16 Pagesis slightly different Distribution Channels - retail, internet, fashion shows, tv, etc Stats - Subculture The extent of culture within America has made way for some unique social subcultures. These subcultural differences come down to the individual and usually depend on social class, political orientation and other demographic characteristics such as religion, occupation and ethnicity. The clothing and fashion industry could be affectedRead MoreChristianity in Rome2890 Words   |  12 Pagesï » ¿ Christianity and the Roman Empire Religion played a key role in the daily life and social system of Ancient Rome. Religion included the worship of many gods and more gods were often adopted from conquered areas. Because most religions were polytheist at the time, the Romans rarely disallowed a cult from a conquered region to continue. A few  cults ran into controversy and opposition from citizens or government, such as the cult of Deus Sol Invictus, and that of Isis. Romans were also not keenRead MoreThe Elements Behind Policing And Police Culture3506 Words   |  15 Pages(Police Culture, 2000). Police officers command a certain respect simply by donning the uniform and carrying a badge. The police culture provides many benefits to individuals who belong to this private organization. Officers of the law have their own social circle that only persons with a badge and uniform are allowed to be a member of. Also, it has been shown that police officers have difficulty in relationships with family members, friends, and personal relationships with significant others. PoliceRead MoreEssay on The Legacy of Romanticism in The Great Gatsby3369 Words   |  14 PagesIn essence, Gatsby’s idealization of Daisy and his reverence for the past convey his romantic yearnings and establish his credentials as a definitive romantic hero. In many respects, the intensity of Gatsby’s love for Daisy and his pledge to win her, exude an innocence and idealism reminiscent of courtly love. When Gatsby returns from Europe, bearing the uniform of the soldier-knight, he makes â€Å"a miserable but irresistible† pilgrimage to Louisville to bask in the â€Å"melancholy beauty†Read MoreAn Essay Against Anti - Social Activities Not More Than 350 Words? Read More: Http: //Wiki.Answers.Coan Essay Against Anti Social Activities Not More Than 3505893 Words   |  24 Pagesbehaviour was rarely used until the 1990s. Throughout the 1980s a couple of articles a year were printed in the UK discussing antisocial behaviour, whereas in January 2004 alone there were over 1,000 such articles (2). Not even the most pessimistic social critic would suggest a parallel increase in problem behaviour. Indeed, in recent years there has been a slight fall in actual vandalism, for example, against a dramatic increase in newspaper mentions of antisocial behaviour (3). When looking at theRead MoreMarketing Management130471 Words   |  522 Pagesintroduction Unit structure: 1. Introduction 2. Learning Objectives 3. Marketing Management 3.1. Evolution of marketing management 3.2. The Role of Marketing 3.3. Marketing concepts 3.4. The Marketing Mix (The 4 P s Of Marketing) 3.5. Corporate Social Responsibility (CSR) and Ethics in Marketing 4. Have you understood type questions 5. Summary 6. Exercises 7. References 1. INTRODUCTION: The apex body in United States of America for the Marketing functions, American Marketing Association (AMA) definesRead MoreStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words   |  1573 PagesManagement Skills 8 †¢ Effective versus Successful Managerial Activities 8 †¢ A Review of the Manager’s Job 9 Enter Organizational Behavior 10 Complementing Intuition with Systematic Study 11 Disciplines That Contribute to the OB Field 13 Psychology 14 †¢ Social Psychology 14 †¢ Sociology 14 †¢ Anthropology 14 There Are Few Absolutes in OB 14 Challenges an d Opportunities for OB 15 Responding to Economic Pressures 15 †¢ Responding to Globalization 16 †¢ Managing Workforce Diversity 18 †¢ Improving Customer ServiceRead MoreDeveloping Management Skills404131 Words   |  1617 Pages mymanagementlab is an online assessment and preparation solution for courses in Principles of Management, Human Resources, Strategy, and Organizational Behavior that helps you actively study and prepare material for class. Chapter-by-chapter activities, including built-in pretests and posttests, focus on what you need to learn and to review in order to succeed. Visit to learn more. DEVELOPING MANAGEMENT SKILLS EIGHTH EDITION David A. Whetten BRIGHAM YOUNG UNIVERSITY

Tuesday, May 5, 2020

Protein Synthesis and Protein Degradation

Question: Discuss about the Protein Synthesis and Protein Degradation. Answer: Introduction: Protein turnover refers to the process by which protein synthesis and protein degradation is balanced. Selective process of protein turnover mediated by ubiquitin therefore refers to protein regulatory process that control degradation of some proteins in cell process. Ubiquitin is 76 amino acid regulatory protein that helps in controlling degradation of selected proteins during protein turnover. According to Tymoczko, Stryer Berg (2002) ubiquitination refers to the addition of ubiquitin to substrate that can signal degradation of the substrate. The following paper describe selective protein turnover of ubiquitin-mediated degradation of keratin in the intermediate filament protein. Degradation of keratin in the intermediate filament occurs through a series of steps that include activation and conjugation, Transesterification, ligation by ubiquitin ligase and Transfer to target protein via E3 to lysine residue intermediate filament protein. Firstly, ubiquitin is activated by ubiquitin activation enzyme E1 that is followed by conjugation of ubiquitin. Secondly, transesterification that involve transfer of ubiquitin to ubiquitin-enzyme E2. Thirdly, the E2 complex is then delivered to ubiquitin-ligase E3 substrate site in the intermediate filament proteins. Fourthly, the keratin protein is delivered via E3 to lysine residue in the intermediate filament protein (Harper Schulman, 2009). In the last step, ubiquitin binds to the lysine residue on the keratin through isopeptide bond. Ubiquitin therefore bind to target protein at different sites and to amino group at N-terminus. The overall result is cleavage of keratins bonds at different amino group and high energy is required in this process. The degradation of ubiquitin- substrate is done by 26S proteasome complex that at the end release reusable ubiquitin and free ubiquitin (Philpott Itzhaki, 2012). Reference Harper, W. Schulman A.(2009) Ubiquitin protein activation. Nature review molecular cell biology 12(5): p. 23-31 Philpott, A Itzhaki, L. (2012) Regulation and control of Proteins Degradation. Biology Open 1(13): p. 136-72 Tymoczko, J. Stryer L Berg, M. (2002) Biochemistry: Protein Turnover. New York : W H Freeman and company.